Solid-state NMR spectroscopy is used to elucidate structural details about proteins that cannot be easily studied by X-ray crystallography, but because the technique is not very sensitive, large sample amounts are required, limiting its biological application. A combination of optimizations now increases the sensitivity of solid-state NMR spectroscopy by up to 5-fold.
- Nalinda P Wickramasinghe
- Sudhakar Parthasarathy
- Yoshitaka Ishii
