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Showing 1–50 of 62 results

Advanced filters: Author: Yoshitaka Shimizu Clear advanced filters

New acoustic monitoring system quantifying aspiration risk during monitored anaesthesia care

Yoshitaka Shimizu
Shinichiro Ohshimo
Nobuaki Shime
ResearchOpen Access18 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
SCOP/PHLPP1β mediates circadian regulation of long-term recognition memory

Learning and memory are subject to circadian variation, though the molecular mechanisms behind this are unclear. Here, the authors show SCOP, a regulator of hippocampal memory, undergoes circadian changes in CA1 membrane raft dynamics and contributes to time-dependent changes in long-term memory.

Kimiko Shimizu
Yodai Kobayashi
Yoshitaka Fukada
ResearchOpen Access30 Sept 2016
Nature Communications

Volume: 7, P: 1-12
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Controlling ²²⁹Th isomeric state population in a VUV transparent crystal

Thorium-229 has the extraordinarily low-energy nuclear state and therefore has potential in atomic clocks. Here, the authors measured the radiative branching fraction of the “clock state”, which is consistent with unity in crystals, and found that this state can be de-populated by X-ray beam irradiation.

Takahiro Hiraki
Koichi Okai
Koji Yoshimura
ResearchOpen Access16 Jul 2024
Nature Communications

Volume: 15, P: 1-10
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

XBB.1.5 of SARS-CoV-2 is a descendant of XBB.1 and has mutations in spike and ORF8, making it more infectious to humans. Here, the authors examined in detail the differences in virological properties of the two variants.

Tomokazu Tamura
Takashi Irie
Takasuke Fukuhara
ResearchOpen Access08 Feb 2024
Nature Communications

Volume: 15, P: 1-17
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Mechanism of self/nonself-discrimination in Brassica self-incompatibility

Self-incompatibility responses in Brassica are induced by haplotype-specific interactions between the pistil-expressed SRK receptor and pollen-expressed SP11 ligand. Here, via crystal structures and molecular dynamic simulations, the authors provide a model to explain why binding of cognate partners is favoured and how haplotypes can be distinguished.

Kohji Murase
Yoshitaka Moriwaki
Seiji Takayama
ResearchOpen Access01 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

XBB is the first recombinant, globally dominant variant of SARS-CoV-2. Here, the authors examine the variant’s origins and virological properties, showing it is the first example of SARS-CoV-2 improving its fitness through recombination.

Tomokazu Tamura
Jumpei Ito
Kei Sato
ResearchOpen Access16 May 2023
Nature Communications

Volume: 14, P: 1-20
Mid- to long-term radiological and respiratory outcomes following surgery for older early-onset scoliosis patients with Marfan syndrome

Yuki Taniguchi
Ryoji Tauchi
Noriaki Kawakami
ResearchOpen Access07 Oct 2024
Scientific Reports

Volume: 14, P: 1-7
A Palindromic Motif in the −2084 to −2078 Upstream Region is Essential for ABCA12 Promoter Function in Cultured Human Keratinocytes

Yoshitaka Shimizu
Yasushi Ogawa
Masashi Akiyama
ResearchOpen Access23 Oct 2014
Scientific Reports

Volume: 4, P: 1-5
Role of Bone Marrow Cells in the Healing Process of Mouse Experimental Glomerulonephritis

Mari Hayakawa
Masamichi Ishizaki
Yoshitaka Fukunaga
Research01 Aug 2005
Pediatric Research

Volume: 58, P: 323-328
A protein language model for exploring viral fitness landscapes

Ito et al. present CoVFit, an AI model that predicts variant fitness (transmissibility) from spike protein sequences alone. They further demonstrate its utility in forecasting viral evolution via single amino acid mutations.

Jumpei Ito
Adam Strange
Kei Sato
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-16
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
DMY is a Y-specific DM-domain gene required for male development in the medaka fish

Masaru Matsuda
Yoshitaka Nagahama
Mitsuru Sakaizumi
Research12 May 2002
Nature

Volume: 417, P: 559-563
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Effects of Dietary Sphingomyelin on Central Nervous System Myelination in Developing Rats

Kyoichi Oshida
Takashi Shimizu
Yuichiro Yamashiro
Research01 Apr 2003
Pediatric Research

Volume: 53, P: 589-593
In-situ observation of ultrafast 90° domain switching under application of an electric field in (100)/(001)-oriented tetragonal epitaxial Pb(Zr_0.4Ti_0.6)O₃ thin films

Yoshitaka Ehara
Shintaro Yasui
Hiroshi Funakubo
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis

Yoshitaka Saito
Tatsuhiko Sakamoto
Mitsuru Sugawara
ResearchOpen Access17 Dec 2022
Scientific Reports

Volume: 12, P: 1-8
Decreased extra-renal urate excretion is a common cause of hyperuricemia

Hyperuricemia, or gout, is thought to arise either from urate overproduction or from decreased renal excretion of urate. Ichidaet al. show that the extra-renal excretion of urate also has a role in the pathogenesis of hyperuricemia, and propose a new classification for patients with this disease.

Kimiyoshi Ichida
Hirotaka Matsuo
Hiroshi Suzuki
ResearchOpen Access03 Apr 2012
Nature Communications

Volume: 3, P: 1-7
Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

JN.1 lineage is a globally dominant variant of SARS-CoV-2. Here, the authors examine structural insights into the BA.2.86 and JN.1 spike dynamics to help understand the mechanisms underlying SARS-CoV-2 infection and its neutralizing-antibody evasion.

Hisano Yajima
Yuki Anraku
Takao Hashiguchi
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-14
The accumulation mechanism of the hypoxia imaging probe “FMISO” by imaging mass spectrometry: possible involvement of low-molecular metabolites

Yukiko Masaki
Yoichi Shimizu
Yuji Kuge
ResearchOpen Access19 Nov 2015
Scientific Reports

Volume: 5, P: 1-9
Complete sequencing and characterization of 21,243 full-length human cDNAs

Toshio Ota
Yutaka Suzuki
Sumio Sugano
Research21 Dec 2003
Nature Genetics

Volume: 36, P: 40-45
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Recent Omicron SARS-CoV-2 subvariants independently acquire 5 key Spike mutations. Here, the authors evaluate the evolutionary importance of the 5 mutations and characterize the virological properties of variant BQ.1.1 harboring all 5 mutations.

Jumpei Ito
Rigel Suzuki
Kei Sato
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-20
Polymaleimides Bearing a Readily Hydrolyzable Side Group: Synthesis and Polymerization of N-Trialkylsilylmaleimides and Characterization of the Polymers

Akikazu Matsumoto
Yoshitaka Oki
Takayuki Otsu
Research01 Jul 1992
Polymer Journal

Volume: 24, P: 679-688
Publisher Correction: Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Yusuke Okuno
Takayuki Murata
Hiroshi Kimura
Amendments and Corrections30 Jan 2019
Nature Microbiology

Volume: 4, P: 544
Mast cell maturation is driven via a group III phospholipase A₂-prostaglandin D₂–DP1 receptor paracrine axis

The mechanisms controlling maturation of mast cells toward an anaphylaxis-sensitive phenotype remain unclear. Murakami and colleagues show that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A₂, regulates this process.

Yoshitaka Taketomi
Noriko Ueno
Makoto Murakami
Research28 Apr 2013
Nature Immunology

Volume: 14, P: 554-563
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Long-term risk of cardiovascular mortality according to age group and blood pressure categories of the latest guideline

Michihiro Satoh
Takayoshi Ohkubo
Yoshitaka Murakami
ResearchOpen Access20 Feb 2025
Hypertension Research

Volume: 48, P: 1428-1433
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc^+/Δ716 Cdx2^+/− compound mutant mice

Koji Aoki
Yoshitaka Tamai
Makoto M Taketo
Research16 Nov 2003
Nature Genetics

Volume: 35, P: 323-330
Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Genome sequencing of fractionated T-, B- and natural killer cells from patients with chronic active Epstein–Barr virus (EBV) infection sheds light on the nature of the EBV-infected progenitor and suggests a link between intragenic EBV deletions and EBV-associated neoplastic proliferations.

Yusuke Okuno
Takayuki Murata
Hiroshi Kimura
Research21 Jan 2019
Nature Microbiology

Volume: 4, P: 404-413
GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Research14 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 155-166
Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor

Taichi Koizumi
Tohru Terada
Takumi Misaka
ResearchOpen Access11 Aug 2015
Scientific Reports

Volume: 5, P: 1-11
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Artificial intelligence can extract important features for diagnosing axillary lymph node metastasis in early breast cancer using contrast-enhanced ultrasonography

Tomohiro Oshino
Ken Enda
Masato Takahashi
ResearchOpen Access15 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Increased levels of oral Streptococcus-derived d-alanine in patients with chronic kidney disease and diabetes mellitus

Yusuke Nakade
Yasunori Iwata
Takashi Wada
ResearchOpen Access16 Dec 2022
Scientific Reports

Volume: 12, P: 1-12
A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection

Yoshitaka Shirasago
Hidesuke Fukazawa
Masayoshi Fukasawa
ResearchOpen Access24 Nov 2022
Scientific Reports

Volume: 12, P: 1-12
Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride

Hotake Takizawa
Yuko Hara
Yoshitsugu Aoki
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
Denaturant-induced helix–coil transition of oligopeptides: theoretical and equilibrium studies of short oligopeptides C17 and AK16

A statistical mechanical theory on the effects of the denaturant molecule on the protein helix–coil transition is developed. The unfolding agents are assumed to attach to the polypeptide backbones and disturb the formation of the hydrogen bond. The polypeptide becomes denaturated by the following reaction: h (helix) ⇌c (random coil) ⇌c* (random coil attached by denaturant). The results obtained from the theory are compared with the experimental result of short oligopeptides.

Fumiaki Kanô
Masaji Shinjo
Hiroshi Kihara
Research02 Feb 2011
Polymer Journal

Volume: 43, P: 293-300
Cervical percutaneous interferential current stimulation improves citric acid cough tests in patients with Parkinson’s disease on medication

Masahiro Nakamori
Megumi Toko
Hirofumi Maruyama
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-8
Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

The virological and pathological features of Omicron subvariants are compared in in vitro cellular and airway-on-a-chip and in vivo hamster models.

Tomokazu Tamura
Daichi Yamasoba
Takasuke Fukuhara
ResearchOpen Access24 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Removal of calciprotein particles from the blood using an adsorption column improves prognosis of hemodialysis miniature pigs

Marina Miura
Yutaka Miura
Makoto Kuro-o
ResearchOpen Access12 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Detection of factors related to treatment reduction in docetaxel and ramucirumab for non-small cell lung cancer treatment

Yoshitaka Saito
Shinya Tamaki
Mitsuru Sugawara
ResearchOpen Access09 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Risk factor analysis for cisplatin-induced nephrotoxicity with the short hydration method in diabetic patients

Yoshitaka Saito
Masaki Kobayashi
Mitsuru Sugawara
ResearchOpen Access10 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Publisher Correction: Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride

Hotake Takizawa
Yuko Hara
Yoshitsugu Aoki
Amendments and CorrectionsOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1
The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity

Loss of the clock gene, Bmal1, in the piriform cortex largely abolishes the circadian rhythm of odor-evoked activity in mice, suggesting a broader regulatory role for Bmal1 in olfactory neural activity and transmission.

Shunsuke Takeuchi
Kimiko Shimizu
Kazuo Emoto
ResearchOpen Access27 Mar 2023
Communications Biology

Volume: 6, P: 1-12
Identification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling

Shinji Kohsaka
Yuichiro Tada
Hiroyuki Mano
ResearchOpen Access04 Nov 2022
npj Precision Oncology

Volume: 6, P: 1-12

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