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Showing 1–3 of 3 results
Advanced filters: Author: Yoshitami Hashimoto Clear advanced filters

  • Topoisomerase 1 (Top1) inhibition is believed to mediate cellular toxicity by trapping Top1 on nicked DNA, leading to double-strand break formation during replication. New studies show that clinically relevant doses of Top1 poisons lead instead to extensive replication-fork reversal that is mediated by Poly(ADP-ribose) polymerases, limiting double-strand break formation.

    • Arnab Ray Chaudhuri
    • Yoshitami Hashimoto
    • Massimo Lopes
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 417-423

  • A system to reconstitute a collapsed replication fork using Xenopus laevis egg extracts is developed. The study shows that upon fork collapse, DNA Pol epsilon and the GINS complex are uncoupled from the replisome, and their reloading onto DNA requires repair proteins Rad51 and Mre11.

    • Yoshitami Hashimoto
    • Fabio Puddu
    • Vincenzo Costanzo
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 17-24