In this Review, Kauffman and colleagues summarize contemporary understanding of the molecular biology underlyingTFE3 and TFEB gene-fusion-associated (translocation) renal cell carcinomas. They discuss the candidate mechanisms and signalling pathways thought to contribute to the oncogenesis of these tumours, and describe TFE3 and TFEBfusion genetic organization.
- Eric C. Kauffman
- Christopher J. Ricketts
- W. Marston Linehan