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Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice

Liver-projecting vagal sensory neurons play a key role in regulating energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. Modulating the liver-brain axis via the vagus nerve may offer a promising therapeutic approach for improving lipid metabolism, glucose homeostasis, and affective disorders in obesity and diabetes.

Jiyeon Hwang
Sangbhin Lee
Young-Hwan Jo
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Synaptic corelease of ATP and GABA in cultured spinal neurons

Young-Hwan Jo
Rémy Schlichter
Research01 Mar 1999
Nature Neuroscience

Volume: 2, P: 241-245
Correction: Corrigendum: Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

So Young Gil
Byung-Soo Youn
Min-Seon Kim
Amendments and Corrections11 Dec 2013
Nature Communications

Volume: 4, P: 1
Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production

Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic neurons in the dorsal motor nucleus of the vagus and that stimulation of this pathway elevates blood glucose levels

Eunjin Kwon
Hye-Young Joung
Young-Hwan Jo
ResearchOpen Access08 Dec 2020
Nature Communications

Volume: 11, P: 1-13
Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons

Hypothalamic POMC neurons regulate organismal energy homeostasis. Here, Lee et al. show that leptin signalling and neurotransmitter release from POMC neurons are influenced by glucose concentrations, which may alter food intake and body weight in rodents before the onset of central leptin resistance.

Dong Kun Lee
Jae Hoon Jeong
Young-Hwan Jo
Research26 Mar 2015
Nature Communications

Volume: 6, P: 1-12
Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

Clusterin is widely distributed in tissues and body fluids, and is implicated in various physiological processes. In this study the authors investigate the role of hypothalamic clusterin, and find that clusterin regulates energy metabolism and body weight through the lipoprotein receptor LRP2.

So Young Gil
Byung-Soo Youn
Min-Seon Kim
Research14 May 2013
Nature Communications

Volume: 4, P: 1-10
Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice

Jae Hoon Jeong
Ji Suk Chang
Young-Hwan Jo
ResearchOpen Access27 Apr 2018
Scientific Reports

Volume: 8, P: 1-14
Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol

You-Young Jo
HaeYong Kweon
Je-Yong Choi
ResearchOpen Access13 Feb 2017
Scientific Reports

Volume: 7, P: 1-11

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