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Signal Transduction and Targeted Therapy (1)
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Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline

Youngpyo Nam
Sehwan Kim
Sang Ryong Kim
ResearchOpen Access12 May 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-3
A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

A screen for inhibitors of microglial activation of neuroinflammation identified the compound ICM, which is anti-inflammatory and neuroprotective by targeting HMGB1 and HMGB2, implicating these proteins in a toxic microglial response.

Sanghee Lee
Youngpyo Nam
Seung Bum Park
Research12 Oct 2014
Nature Chemical Biology

Volume: 10, P: 1055-1060
Intracerebellar upregulation of Rheb(S16H) ameliorates motor dysfunction in mice with SCA2

Sehwan Kim
Junwoo Park
Sang Ryong Kim
Research03 Mar 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1852-1863
Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation

Jungwan Hong
Dongyeong Yoon
Sang Ryong Kim
ResearchOpen Access07 Aug 2020
Scientific Reports

Volume: 10, P: 1-10