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Showing 1–16 of 16 results
Advanced filters: Author: Yousuke Takahama Clear advanced filters

  • There are few methods available that can quantify relationships between cell types in tissue images. Here the authors present a quantitative method to evaluate cellular organization, validated in the mouse thymus and spinal cord, called Multitaper Circularly Averaged Spectral Analysis (MiCASA).

    • Andrew Sornborger
    • Jie Li
    • Nancy R. Manley
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • As thymocytes travel through the thymus, they not only receive signals from stromal cells but also deliver signals to stromal cells to generate the appropriate stromal environment. Takahama describes the factors involved in this lympho–stromal crosstalk for thymocyte trafficking and T-cell-repertoire selection.

    • Yousuke Takahama
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 127-135

  • In the thymus, low-affinity T cell antigen receptor (TCR) engagement facilitates positive selection of the T cell repertoire. Takahama and colleagues now show TCR responsiveness of mature CD8+ T cells is fine-tuned by their affinity for positively selecting peptides in the thymus.

    • Kensuke Takada
    • Francois Van Laethem
    • Yousuke Takahama
    Research
    Nature Immunology
    Volume: 16, P: 1069-1076

  • Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now identified that the peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance.

    • Yousuke Takahama
    News & Views
    Nature Aging
    Volume: 5, P: 534-535

  • The 'choice' between the CD4+CD8− and CD4−CD8+ T cell lineage involves genomic specification via a set of transcription factors. A new study shows that the zinc-finger protein MAZR is another member of this transcription factor network.

    • Kensuke Takada
    • Yousuke Takahama
    News & Views
    Nature Immunology
    Volume: 11, P: 370-371

  • The generation of a diverse T cell repertoire depends on heterogeneous populations of thymic epithelial cells (TECs). Here, the authors explain how different subsets of TECs support and coordinate different stages of T cell development to ensure the selection of a functional and self-tolerant T cell repertoire.

    • Yousuke Takahama
    • Izumi Ohigashi
    • Graham Anderson
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 295-305

  • Foxn1 is involved in thymic epithelial cell (TEC) and CD8+T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.

    • Muhammad Myn Uddin
    • Izumi Ohigashi
    • Yousuke Takahama
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Proteasomes digest intracellular proteins into peptides that are then presented to lymphocytes as antigens. Here the authors show that a thymic epithelium-specific proteasome subunit cuts model proteins in a pattern favouring their weak binding to T cell receptor, and thus T cell positive selection.

    • Katsuhiro Sasaki
    • Kensuke Takada
    • Shigeo Murata
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10

  • Although the importance of thymic epithelial cells (TEC) in thymus physiology is established, the development of functionally diverse TEC populations remains incompletely understood. Here, using fate-mapping experiments in the embryonic thymus, the authors identify keratin19+ multipotent progenitor cells that support medullary TEC diversity in adulthood.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Activated B cell enter germinal centers (GC) to become plasma cells and memory B cells. Here the authors show that some memory B cells recycle to GC via CCL-21 mediated chemotaxis to deliver antigens from the lymph node subcapsular sinus (SCS) to potentially contribute to affinity maturation and antigenic drift.

    • Yang Zhang
    • Laura Garcia-Ibanez
    • Kai-Michael Toellner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of mTEC for specific control of multiple lineages of invariant natural killer T cells.

    • Beth Lucas
    • Andrea J. White
    • Graham Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-dependent genetic program to ensure a rapid increase in thymus size, and thereby expedited T cell generation.

    • Jennifer E. Cowan
    • Justin Malin
    • Avinash Bhandoola
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The immunoproteasome and thymoproteasome are specialized proteasomes operating within the immune system. In this Review, Murata et al. recount the discovery of the immunoproteasome and thymoproteasome and delve into their function, context in evolution and relation to human disease.

    • Shigeo Murata
    • Yousuke Takahama
    • Keiji Tanaka
    Reviews
    Nature Immunology
    Volume: 19, P: 923-931