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Showing 1–2 of 2 results
Advanced filters: Author: Yu Kitago Clear advanced filters
  • The neuronal sorting receptor SorLA protects against Alzheimer's disease by binding Aβ peptides. Three new structures of the Vps10p Aβ-binding domain in ligand-free and ligand-bound forms explain the basis of SorLA peptide recognition.

    • Yu Kitago
    • Masamichi Nagae
    • Junichi Takagi
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 199-206
  • The activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis but its mechanism of action is poorly understood. Here, the authors solve crystal structures of free and substrate analog-bound GnT-V, providing insights into its catalytic mechanism and a basis for GnT-V inhibition.

    • Masamichi Nagae
    • Yasuhiko Kizuka
    • Yoshiki Yamaguchi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12