Mak and colleagues report that TRADD, an adaptor protein important in tumour necrosis factor receptor (TNFR) signalling, contributes to tumour suppression independently of TNFR. They show that nuclear TRADD binds to the tumour suppressor p19Arf and inhibits its interaction with the E3 ubiquitin ligase ULF, leading to p19Arf stability and promoting cell senescence.
- Iok In Christine Chio
- Masato Sasaki
- Tak Wah Mak
