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Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.

Yu-Jie Li
Yu-Lu Cao
Song Gao
ResearchOpen Access29 Oct 2019
Nature Communications

Volume: 10, P: 1-14
Combining chemical and genetic approaches to increase drought resistance in plants

Plants respond to abiotic stress via the phytohormone ABA. Here, Cao et al. report a series of new ABA receptor agonists, named AMFs, which have higher receptor-binding affinities and show that, when employed in tandem with ABA receptor overexpression, can significantly increase drought resistance

Min-Jie Cao
Yu-Lu Zhang
Jian-Kang Zhu
ResearchOpen Access30 Oct 2017
Nature Communications

Volume: 8, P: 1-12
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis

Here, the authors show how Aurora kinase A (AURKA) employs Rab1a to direct ER remodeling. Activated Rab1A is retained on the ER and directly interacts with the RTN/REEP ER-shaping machinery to promote its oligomerization, eventually triggering an increase of ER complexity during mitosis.

Wei Zhang
Zijian Zhang
Quentin Liu
Research04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 219-231
Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment

Epstein-Barr virus (EBV) tegument proteins BBRF2 and BSRF1 have been suggested to form a hetero-complex. Here, He et al. provide the crystal structures of BBRF2 alone and in complex with BSRF1 and suggest that the complex tethers EBV nucleocapsids to the Golgi membrane, facilitating secondary envelopment.

Hui-Ping He
Meng Luo
Song Gao
ResearchOpen Access26 Oct 2020
Nature Communications

Volume: 11, P: 1-14
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

Bin Lu
Yi-yun Sun
Bo Yang
Research17 Jul 2025
Acta Pharmacologica Sinica

P: 1-12
MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Crystal structures of engineered human MFN1 in different stages of GTP hydrolysis provide insights into the GTP-induced conformational changes that promote MFN1 dimerization to bring about mitochondrial fusion.

Yu-Lu Cao
Shuxia Meng
Song Gao
Research23 Jan 2017
Nature

Volume: 542, P: 372-376

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Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Combining chemical and genetic approaches to increase drought resistance in plants

Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis

Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

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Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Combining chemical and genetic approaches to increase drought resistance in plants

Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis

Structure of Epstein-Barr virus tegument protein complex BBRF2-BSRF1 reveals its potential role in viral envelopment

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Search

Quick links