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Advanced filters: Author: Yuandi Gao Clear advanced filters

A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Formaldehyde can trigger formation of interstrand crosslinks (ICLs) or DNA-protein crosslinks (DPCs) leading to genome instability. Here the authors show that EXO1 limits replication stress and DNA damage to counteract formaldehyde-induced genome instability.

Yuandi Gao
Laure Guitton-Sert
Jean-Yves Masson
ResearchOpen Access24 Jan 2023
Nature Communications

Volume: 14, P: 1-20
Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo

Xuan Zhao
WenLiang Dong
JunYing Miao
ResearchOpen Access20 Jun 2017
Scientific Reports

Volume: 7, P: 1-11

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A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Novel indolyl-chalcone derivatives inhibit A549 lung cancer cell growth through activating Nrf-2/HO-1 and inducing apoptosis in vitro and in vivo

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