UNC119 is a protein localized to the non-motile primary cilia. Here, Zhang et al. report the crystal structure of UNC119 and provide biochemical and cellular evidence that UNC119 is a lipid-binding protein that mediates G protein trafficking. The authors also show that that UNC119 function is conserved from GPCR trafficking in C. elegans olfactory neuron to transducin trafficking in mammalian photoreceptors.
- Houbin Zhang
- Ryan Constantine
- Wolfgang Baehr
