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Targeting SLP2-mediated lipid metabolism reprograming restricts proliferation and metastasis of hepatocellular carcinoma and promotes sensitivity to Lenvatinib

Yufeng Liu
Linmao Sun
Lianxin Liu
Research06 Dec 2022
Oncogene

Volume: 42, P: 374-388
Xenogeneic-free culture of human intestinal stem cells on functional polymer-coated substrates for scalable, clinical-grade stem cell therapy

Methods to culture intestinal stem cells (ISCs) are often limited by undefined culture conditions arising from the use of basement membrane extracts or feeder cell layers. Here, the authors propose a polymer-based xenogeneic-free dish to culture stem cells, ensuring extended maintenance of ISCs derived from 3D human intestinal organoids.

Seonghyeon Park
Ohman Kwon
Sung Gap Im
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-18
The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation

Microbiome-secreted proteins act as key modulators of host-microbiome crosstalk. Here, the authors show that Amuc_1409 protein, secreted from Akkermansia muciniphila, plays a key role in intestinal homeostasis by regulating intestinal stem cells through interaction with E-cadherin, indicating its potential as a biomolecule for improving gut health.

Eun-Jung Kang
Jae-Hoon Kim
Chul-Ho Lee
ResearchOpen Access06 Apr 2024
Nature Communications

Volume: 15, P: 1-20

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