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Showing 1–3 of 3 results

Advanced filters: Author: Yuechao Wu Clear advanced filters

High performance TadA-8e derived cytosine and dual base editors with undetectable off-target effects in plants

Base editors are a powerful but underexplored tool for genetic engineering and directed evolution of plants. Here, the authors investigate the editing efficiency and specificity of TadA-8e-derived cytosine base editors and dual base editor TadDE in rice and tomato.

Tingting Fan
Yanhao Cheng
Yong Zhang
ResearchOpen Access14 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

Rhomboid proteins are involved in human cancer progression. Here, the authors show that RHBDD1, a rhomboid intramembrane serine protease, promotes tumor growth in colorectal cancer via cleavage and secretion of TGFα, and activation of the EGFR/Raf/MEK/ERK signalling pathway.

Wei Song
Wenjie Liu
Linfang Wang
ResearchOpen Access24 Aug 2015
Nature Communications

Volume: 6, P: 1-13
An efficient CRISPR–Cas12a promoter editing system for crop improvement

A CRISPR–Cas12a promoter editing system enabled efficient engineering of quantitative trait variations of grain starch and seed size in rice, and achieved an innovative Green Revolution trait through editing of the OsD18 promoter.

Jianping Zhou
Guanqing Liu
Yong Zhang
Research06 Apr 2023
Nature Plants

Volume: 9, P: 588-604