Nature Search

Epigenetic control of topoisomerase 1 activity presents a cancer vulnerability

DNA transactions promote torsional constraints that pose inherent risks to genome integrity. Here the authors identify the macro-histone splice variant macroH2A1.1 as an epigenetic modulator of topoisomerase 1-associated genome maintenance. MacroH2A1.1 expression determines sensitivity to TOP1 poisons and may present a cancer vulnerability.

Tae-Hee Lee
Colina X. Qiao
Philipp Oberdoerffer
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging

A two-step, video-based deep learning model is developed to first screen for cardiac anomalies using noncontrast magnetic resonance imaging, followed by diagnosis of 11 types of cardiovascular disease using gadolinium enhancement-based imaging.

Yan-Ran (Joyce) Wang
Kai Yang
Shihua Zhao
ResearchOpen Access13 May 2024
Nature Medicine

Volume: 30, P: 1471-1480
Sulfate formation is dominated by manganese-catalyzed oxidation of SO₂ on aerosol surfaces during haze events

Sulfate aerosols are an important component of wintertime haze events in China, but their production mechanisms are not well known. Here, the authors show that transition metal-catalyzed oxidation of SO₂ on aerosol surfaces could be the dominant sulfate formation pathway in Northern China.

Weigang Wang
Mingyuan Liu
Maofa Ge
ResearchOpen Access31 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Secure thermal infrared communications using engineered blackbody radiation

Xiaoxin Liang
Fangjing Hu
Stepan Lucyszyn
ResearchOpen Access10 Jun 2014
Scientific Reports

Volume: 4, P: 1-7
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy

Optogenetics makes use of light-sensitive proteins to control biological processes using light. Here, the authors present an optogenetic system that regulates the cGAS/STING pathway remotely and demonstrate its efficacy in murine tumour models.

Yaling Dou
Rui Chen
Yun Huang
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Lithiophilic-lithiophobic gradient interfacial layer for a highly stable lithium metal anode

Lithium metal batteries suffer from the dendrite growth upon electrochemical cycling. Here the authors introduce a lithiophilic-lithiophobic gradient interfacial ZnO/CNT layer, which facilitates the formation of a stable solid electrolyte interphase, and suppresses the growth of lithium dendrite.

Huimin Zhang
Xiaobin Liao
Hao Zhang
ResearchOpen Access13 Sept 2018
Nature Communications

Volume: 9, P: 1-11
GSDMD enhances cisplatin-induced apoptosis by promoting the phosphorylation of eIF2α and activating the ER-stress response

Qianyu Zhang
Zixian Huang
Zhiquan Huang
ResearchOpen Access14 Mar 2022
Cell Death Discovery

Volume: 8, P: 1-13
O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia

Yinrui Lei
Tao Chen
Ting Wang
ResearchOpen Access14 Feb 2020
Oncogenesis

Volume: 9, P: 1-12

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