Magneto-core–shell nanoassemblies by loading μ-oxo-bridged Fe complex (Fe(salen) (core)) inside PCL-b-PPy block copolymers (shell) are fabricated, without the use of common magnetites and toxic solvents. By taking a surface functionalization with natural biomolecules (bovine serum albumin/gum arabic (BSA/GA)), the nanoassemblies endow to hold tunablity of core-size and magnetism, biocompatibility, and colloidal stability. Moreover, distinguishing their multifunctional features of cancer targeting include magneto-guided drug delivery, MRI, and triggered hyperthermia in responsive to multi (magnetic, thermo, and pH) stimuli, which allow them a promising potential for a wide-variety of ‘minimally-invasive’ theranostic clinics, as an alternative candidate to conventional magnetite-based anticancer targeting.
- Jeong-Hwan Kim
- Haruki Eguchi
- Yoshihiro Ishikawa
