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Showing 1–2 of 2 results
Advanced filters: Author: Yukiko Michibata Clear advanced filters

  • Cell-type-specific activation of receptors is desirable for elucidating their roles in tissues or animals. Here, the authors developed a chemogenetic method for direct activation of mGlu1, a GPCR-type glutamate receptor subtype, and demonstrate its use in mouse brain tissue.

    • Kento Ojima
    • Wataru Kakegawa
    • Shigeki Kiyonaka
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The controlled activation of proteins inside living cells is an important goal in protein design research. Now, a strategy for allosteric activation using coordination chemistry has been demonstrated for two different kinds of neurotransmitter receptors, an ion-channel and a G-protein coupled glutamate receptor.

    • Shigeki Kiyonaka
    • Ryou Kubota
    • Itaru Hamachi
    Research
    Nature Chemistry
    Volume: 8, P: 958-967