Epithelial cell transforming sequence 2 (ECT2), a guanine nucleotide exchange factor, is localized in both the nucleus and cytoplasm of cell lines and resected lung adenocarcinomas. In this article, the authors show that cytoplasmic expression of ECT2 is associated with poor outcomes and that positive P-ECT2(T790) staining correlates with cytoplasmic ECT2 expression. Furthermore, cytoplasmic ECT2 expression promotes the malignant progression of lung adenocarcinoma.
- Zeinab Kosibaty
- Yoshihiko Murata
- Masayuki Noguchi
