Role of O-linked-N-acetylglucosamine modification (O-GlcNAcylation) in mineralocorticoid receptor (MR) expression and transcriptional activity. Aldosterone binding promotes the proteasomal degradation of MR. O-GlcNAcylation of MR inhibits ubiquitin attachment to the MR and interferes with the receptor’s aldosterone-induced proteasomal degradation. As a result, O-GlcNAcylation increases the sensitivity of the MR to aldosterone and exacerbates aldosterone-associated complications (resistant hypertension, diabetic nephropathy and cardiovascular diseases).
- Rie Jo
- Hirotaka Shibata
- Hiroshi Itoh
