Nature Search

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Ken Suzuki
Konstantinos Hatzikotoulas
Eleftheria Zeggini
ResearchOpen Access19 Feb 2024
Nature

Volume: 627, P: 347-357
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.

Scisung Chung
Mi-Sun Kang
Yunje Cho
ResearchOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Jianxin Shi
Kouya Shiraishi
Qing Lan
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-17
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

Anubha Mahajan
Min Jin Go
Andrew P Morris
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 234-244
F-box only protein 9 is an E3 ubiquitin ligase of PPARγ

Kyeong Won Lee
Soo Heon Kwak
Kyong Soo Park
ResearchOpen Access20 May 2016
Experimental & Molecular Medicine

Volume: 48, P: e234
Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3–4 (2015–2020)

Ji-youn Lee
Yun-Hee Choi
Kyong Whan Moon
ResearchOpen Access17 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Yoon Shin Cho, Mark Seielstad and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes in individuals of east Asian ancestry. They identify eight new loci associated with type 2 diabetes.

Yoon Shin Cho
Chien-Hsiun Chen
Mark Seielstad
Research11 Dec 2011
Nature Genetics

Volume: 44, P: 67-72
Efficacy of a local anesthetic gel infusion kit for pain relief after minimally invasive colorectal surgery: an open-label, randomized clinical trial

Jung Kyong Shin
Heejoon Jeong
Hee Cheol Kim
ResearchOpen Access19 Oct 2022
Scientific Reports

Volume: 12, P: 1-10
Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)⁺ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy expenditure by regulating hypothalamic NAD⁺ levels.

Jae Woo Park
Eun Roh
Min-Seon Kim
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Altered branching patterns of Purkinje cells in mouse model for cortical development disorder

Jinkyung Kim
Namseop Kwon
Im Joo Rhyu
ResearchOpen Access18 Oct 2011
Scientific Reports

Volume: 1, P: 1-7
CO₂-Selective Nanoporous Metal-Organic Framework Microcantilevers

Changyong Yim
Moonchan Lee
Sangmin Jeon
ResearchOpen Access02 Jun 2015
Scientific Reports

Volume: 5, P: 1-8
Cultured cambial meristematic cells as a source of plant natural products

The culture of dedifferentiated plant cells to produce commercially important chemicals has met with limited success. Lee et al. demonstrate the potential of innately undifferentiated cells from Taxus cuspidata as an industrial source of the anticancer drug paclitaxel.

Eun-Kyong Lee
Young-Woo Jin
Gary J Loake
Research24 Oct 2010
Nature Biotechnology

Volume: 28, P: 1213-1217
Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Sung-Il Yun
Sang-Kyu Lee
Han-Oh Park
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-15
Tailoring the grain boundary structure and chemistry of the dendrite-free garnet solid electrolyte Li_6.1Ga_0.3La₃Zr₂O₁₂

The addition of Li2O-B2O3-Al2O3 (LBA) sintering aid to Li_6.1Ga_0.3La₃Zr₂O₁₂ (LGLZO) solid electrolytes enhances grain boundary characteristics and reduces porosity. This modification leads to a substantial increase in ionic conductivity and mechanical stability, while effectively preventing Li dendrite formation. The optimized LGLZO sample with LBA exhibits improved long-term cycling performance, making it a promising candidate for high-performance all-solid-state batteries. These findings underscore the critical role of grain boundary engineering in enhancing the electrochemical properties of garnet-type electrolytes.

Rae-Hyun Lee
Chea-Yun Kang
Seung-Hwan Lee
ResearchOpen Access30 Aug 2024
NPG Asia Materials

Volume: 16, P: 1-12
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Overexpression of Cyclooxygenase-2 Is Associated with Breast Carcinoma and Its Poor Prognostic Factors

Jeong Yun Shim
Hee Jung An
Kyong Sik Lee
Research01 Dec 2003
Modern Pathology

Volume: 16, P: 1199-1204
Author Correction: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Sung-Il Yun
Sang-Kyu Lee
Han-Oh Park
Amendments and CorrectionsOpen Access05 Apr 2022
Scientific Reports

Volume: 12, P: 1-2
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Qing Lan and colleagues report the results of a genome-wide association study of lung cancer in never-smoking women from Asia. They identify three new susceptibility loci and confirm three other previously reported associations.

Qing Lan
Chao A Hsiung
Nathaniel Rothman
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1330-1335
A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes

Dohyun Lee
Woo-Sirl Lee
Sung-Kee Chung
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-9
Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT

Ara Cho
Wencheng Jin
Jung Pyo Lee
ResearchOpen Access16 Oct 2023
Scientific Reports

Volume: 13, P: 1-13
Socioeconomic burden of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa in Korea

Chung-Jong Kim
Kyoung-Ho Song
Young-Jun Kim
ResearchOpen Access17 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
The effects of socioeconomic and geographic factors on chronic phase long-term survival after stroke in South Korea

Dougho Park
Su Yun Lee
Hyoung Seop Kim
ResearchOpen Access14 Mar 2022
Scientific Reports

Volume: 12, P: 1-11
A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis

Kieun Bae
Jin Hee Kim
Kyong-Ah Yoon
ResearchOpen Access18 Nov 2020
British Journal of Cancer

Volume: 124, P: 290-298
Clinical prediction model of pathological response following neoadjuvant chemoradiotherapy for rectal cancer

Jung Kyong Shin
Jung Wook Huh
Yoon Ah Park
ResearchOpen Access03 May 2022
Scientific Reports

Volume: 12, P: 1-10
Minimally invasive versus open intersphincteric resection of low rectal cancer regardless of neoadjuvant chemoradiotherapy: long-term oncologic outcomes

Jung kyong Shin
Hee Cheol Kim
Yoon Ah Park
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-10
Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults

Ji-Hee Haam
Young-Sang Kim
Moon Jong Kim
ResearchOpen Access13 May 2021
Scientific Reports

Volume: 11, P: 1-9
Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
ResearchOpen Access03 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment

Tae Jung Oh
Woo Jun Sul
Hak Chul Jang
ResearchOpen Access30 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Nicholas A. Enzer
Joe Chiles
Mario E. Ruiz
Amendments and CorrectionsOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1

Search

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

The power of genetic diversity in genome-wide association studies of lipids

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

F-box only protein 9 is an E3 ubiquitin ligase of PPARγ

Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3–4 (2015–2020)

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Efficacy of a local anesthetic gel infusion kit for pain relief after minimally invasive colorectal surgery: an open-label, randomized clinical trial

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Altered branching patterns of Purkinje cells in mouse model for cortical development disorder

CO₂-Selective Nanoporous Metal-Organic Framework Microcantilevers

Cultured cambial meristematic cells as a source of plant natural products

Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Tailoring the grain boundary structure and chemistry of the dendrite-free garnet solid electrolyte Li_6.1Ga_0.3La₃Zr₂O₁₂

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Overexpression of Cyclooxygenase-2 Is Associated with Breast Carcinoma and Its Poor Prognostic Factors

Author Correction: Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes

Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT

Socioeconomic burden of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa in Korea

The effects of socioeconomic and geographic factors on chronic phase long-term survival after stroke in South Korea

A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis

Clinical prediction model of pathological response following neoadjuvant chemoradiotherapy for rectal cancer

Minimally invasive versus open intersphincteric resection of low rectal cancer regardless of neoadjuvant chemoradiotherapy: long-term oncologic outcomes

Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults

Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Butyrate attenuated fat gain through gut microbiota modulation in db/db mice following dapagliflozin treatment

Author Correction: Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area

Search

Quick links

Search

Filter By:

Search

Quick links