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Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Ann-Na Cho
Yoonhee Jin
Seung-Woo Cho
ResearchOpen Access05 Aug 2021
Nature Communications

Volume: 12, P: 1-23
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli

A two-cell setup containing tryptophanase, a flavin-dependent monooxygenase and a regiospecific halogenase (linked to a flavin reductase as a solubility tag) enables the production of 6,6'-dibromoindigo and other indigoid dyes in Escherichia coli.

Jeongchan Lee
Joonwon Kim
Byung-Gee Kim
Research02 Nov 2020
Nature Chemical Biology

Volume: 17, P: 104-112
Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma

Won-Suk Song
Hae-Min Park
Yun-Gon Kim
ResearchOpen Access23 Jul 2018
Scientific Reports

Volume: 8, P: 1-8
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

Hydrogels made from decellularized human brain tissue facilitate the direct conversion of primary mouse embryonic fibroblasts into induced neuronal cells that lead to therapeutic outcomes after transplantation in an animal model of ischaemic stroke.

Yoonhee Jin
Jung Seung Lee
Seung-Woo Cho
Research11 Jul 2018
Nature Biomedical Engineering

Volume: 2, P: 522-539
Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

The application of engineered cardiac tissues is limited due to their immaturity and lack of functionality. Here, the authors develop an integrated culture platform featuring heart extracellular matrix cultured in a microfluidic chip to facilitate cardiac tissue development for versatile biomedical applications.

Sungjin Min
Suran Kim
Seung-Woo Cho
ResearchOpen Access22 Mar 2024
Nature Communications

Volume: 15, P: 1-22
A MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells

Kyoung-Jin Kim
Hee-Jin Kim
Yun-Gon Kim
ResearchOpen Access19 Apr 2016
Scientific Reports

Volume: 6, P: 1-7
Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids

The culture of gastrointestinal organoids relies on Matrigel that has several drawbacks for clinical application. Here, the authors report the feasibility of gastrointestinal tissue-mimetic matrices as effective alternatives to Matrigel for organoid culture and transplantation.

Suran Kim
Sungjin Min
Seung-Woo Cho
ResearchOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1-21
Investigation of antioxidant and anticancer activities of unsaturated oligo-galacturonic acids produced by pectinase of Streptomyces hydrogenans YAM1

Afrouzossadat Hosseini Abari
Hamed Amini Rourani
Yun-Gon Kim
ResearchOpen Access19 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli

Junyoung Kim
Hyung-Min Seo
Yung-Hun Yang
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Chemical Structure of the Lipid A component of Pseudomonas sp. strain PAMC 28618 from Thawing Permafrost in Relation to Pathogenicity

Han-Gyu Park
Ganesan Sathiyanarayanan
Yun-Gon Kim
ResearchOpen Access19 May 2017
Scientific Reports

Volume: 7, P: 1-12
Analysis of the proteolysis of bioactive peptides using a peptidomics approach

Yun-Gon Kim
Anna Mari Lone
Alan Saghatelian
Protocols15 Aug 2013
Nature Protocols

Volume: 8, P: 1730-1742

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Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli

Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications

A MALDI-MS-based quantitative analytical method for endogenous estrone in human breast cancer cells

Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids

Investigation of antioxidant and anticancer activities of unsaturated oligo-galacturonic acids produced by pectinase of Streptomyces hydrogenans YAM1

Production of itaconate by whole-cell bioconversion of citrate mediated by expression of multiple cis-aconitate decarboxylase (cadA) genes in Escherichia coli

Chemical Structure of the Lipid A component of Pseudomonas sp. strain PAMC 28618 from Thawing Permafrost in Relation to Pathogenicity

Analysis of the proteolysis of bioactive peptides using a peptidomics approach

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