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The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

Embryonic stem cell differentiation requires activation of lineage-specific genes. Here the authors show that the histone H2A deubiquitinase Usp16 is required for relieving ubiquitinated H2A-mediated silencing of lineage-specific genes and embryonic stem cell differentiation.

Wei Yang
Yun-Hwa Lee
Hengbin Wang
Research02 May 2014
Nature Communications

Volume: 5, P: 1-15

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The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment

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