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Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis

Smad signalling has been implicated in tumour and metastases formation. Here, Tang et al.show that profilin-2 enhances Smad signalling and tumour growth via an epigenetic mechanism, and that Smad expression correlates with an unfavourable prognosis of lung cancer patients.

Yun-Neng Tang
Wei-Qiao Ding
Jian-Guo Song
Research10 Sept 2015
Nature Communications

Volume: 6, P: 1-15

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