TDP-43 proteinopathies are characterized by TDP-43 aggregates but the relationship of these aggregates to the pathogenesis is still not well defined. Here, the authors show that the recombinant full-length human TDP-43 forms oligomers that are neurotoxic, can promote the formation of A-beta amyloid oligomers in vitroand can be detected in postmortem brain of patients.
- Yu-Sheng Fang
- Kuen-Jer Tsai
- Yun-Ru Chen
