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Human amniotic fluid stem cells can alleviate detrusor dysfunction caused by bladder outlet obstruction in rats

Ching-Chung Liang
Wen-Chu Huang
Tsong-Hai Lee
ResearchOpen Access23 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
Clonal inactivation of TERT impairs stem cell competition

Studies in mice show that telomerase reverse transcriptase (TERT) has a role in enhancing stem cell competition that is independent of its reverse transcriptase activity, and promotes chromatin accessibility and activity of the MYC oncogene.

Kazuteru Hasegawa
Yang Zhao
Steven E. Artandi
ResearchOpen Access17 Jul 2024
Nature

Volume: 632, P: 201-208
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

Understanding how DNA methylation regulates gene expression requires the capacity to deploy it to regions of interest. The authors generate a highly rapid and locus-specific CpG methylation tool by fusing dCas9 to MQ1 DNA methyltransferase and show efficacy at multiple sitesin vitro and in vivo.

Yong Lei
Xiaotian Zhang
Margaret A. Goodell
ResearchOpen Access11 Jul 2017
Nature Communications

Volume: 8, P: 1-10
Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas

Yu-Chi Wang
Chi-Cheng Chuang
Pin-Yuan Chen
ResearchOpen Access20 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Improvement in bladder dysfunction after bladder transplantation of amniotic fluid stem cells in diabetic rats

Ching-Chung Liang
Sheng-Wen Steven Shaw
Tsong-Hai Lee
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Margaret Goodell, Wei Li and colleagues use double-knockout mice for Dnmt3a and Tet2 to model leukemia development. Through epigenetic and transcriptional analyses, they show that loss of DNMT3A and TET2 upregulates lineage-specific transcription factors such as KLF1 in hematopoietic stem cells and accelerates malignancy.

Xiaotian Zhang
Jianzhong Su
Margaret A Goodell
Research18 Jul 2016
Nature Genetics

Volume: 48, P: 1014-1023
Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women

Ching-Chung Liang
Wu-Chiao Hsieh
Yung-Hsin Huang
ResearchOpen Access08 Nov 2023
Scientific Reports

Volume: 13, P: 1-9
Effect of amniotic fluid stem cell transplantation on the recovery of bladder dysfunction in spinal cord-injured rats

Ching-Chung Liang
Sheng-Wen Steven Shaw
Tsong-Hai Lee
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-14
MorPhiC Consortium: towards functional characterization of all human genes

This Perspective discusses strategies and challenges for the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) Consortium as it aims to catalogue the molecular and cellular phenotypes associated with null alleles of all human genes.

Mazhar Adli
Laralynne Przybyla
Justina Žurauskienė
Reviews12 Feb 2025
Nature

Volume: 638, P: 351-359

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Human amniotic fluid stem cells can alleviate detrusor dysfunction caused by bladder outlet obstruction in rats

Clonal inactivation of TERT impairs stem cell competition

Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

Long Term Surgical Outcome and Prognostic Factors of Atypical and Malignant Meningiomas

Improvement in bladder dysfunction after bladder transplantation of amniotic fluid stem cells in diabetic rats

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Urinary beta 3-adrenoceptor as a diagnostic biomarker for overactive bladder in women

Effect of amniotic fluid stem cell transplantation on the recovery of bladder dysfunction in spinal cord-injured rats

MorPhiC Consortium: towards functional characterization of all human genes

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