PACS1 syndrome is caused by an Arg203Trp mutation in PACS1. Here, the authors show that PACS1R203Wdysregulates HDAC6 to disturb neuronal structure and function in a mouse model, and that silencing PACS1R203W/HDAC6 reverses these deficits.
- Sabrina Villar-Pazos
- Laurel Thomas
- Gary Thomas