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Structural basis for the dynamic conformations of AP-4 and its association with ARF1

AP-4 assembles non-clathrin coats for membrane trafficking. Here, authors present the structures of AP-4 and the AP-4/ARF1 complex, revealing its dynamic conformations essential for synergistic engagement of ARF1 and cargoes for membrane recruitment.

Yanghui Wang
Wei Li
Wei Feng
ResearchOpen Access21 Jan 2026
Nature Communications

Volume: 17, P: 1-20
Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture

Kidney stone disease is a complex disorder with high heritability and prevalence. Here, the authors perform a large genome-wide association study meta-analysis, identifying 28 new loci and genes potentially involved in disease etiology.

Xingjie Hao
Zhonghe Shao
Chaolong Wang
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Targeting PLK1-CBX8-GPX4 axis overcomes BRAF/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis

Dual targeting of BRAF and MAPK signaling in the BRAF v600E mutant colorectal cancer patients has shown limited efficacy in clinical studies. Here, the authors identify PLK1 inhibition as synthetic lethal with dual BRAF and EGFR inhibition due to loss of ferroptosis inhibition via a PLK1-CBX8-GPX4 signaling axis in preclinical models of colorectal cancer.

Zhan Zhao
Jiashuai He
Jinghua Pan
ResearchOpen Access16 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Transport mechanism of presynaptic high-affinity choline uptake by CHT1

The authors report the structures of human CHT1 in the outward-open, inward-occluded and inward-open states, reveal the mechanism of HC-3 inhibition and choline recognition and elucidate the regulatory role of the intracellular helix IH1.

Yunlong Qiu
Yiwei Gao
Yan Zhao
Research08 Apr 2024
Nature Structural & Molecular Biology

Volume: 31, P: 701-709
Dopamine reuptake and inhibitory mechanisms in human dopamine transporter

Structural analyses of the human dopamine transporter in apo and substrate-bound states and in complex with drugs and inhibitors reveal key binding residues and conformational transitions that occur during substrate transport.

Yue Li
Xianping Wang
Yan Zhao
Research07 Aug 2024
Nature

Volume: 632, P: 686-694
Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators

Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and identify the transcription factors TCF3 and TCF12 as key regulators of folliculogenesis.

Bofeng Liu
Yuanlin He
Wei Xie
Research05 Jun 2024
Nature Cell Biology

Volume: 26, P: 962-974
Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca_V2.3

The Ca_V2.3 channel is involved in synaptic plasticity and neurological disorders. Here, authors resolve the human Ca_V2.3 structure to explore functional heterogeneity of VSDs and elucidated the closed- and open-state inactivation mechanisms of the channel.

Yiwei Gao
Shuai Xu
Yan Zhao
ResearchOpen Access31 Jan 2023
Nature Communications

Volume: 14, P: 1-12
Structure of human Na_V1.6 channel reveals Na⁺ selectivity and pore blockade by 4,9-anhydro-tetrodotoxin

Na_V1.6 channel plays a critical role in neuronal excitability. Here, authors present human Na_V1.6 structures in apo and 4,9-anhydro-tetrodotoxin bound forms, which reveal molecular mechanisms of Na_V1.6 Na⁺ conductance and inhibition by the blocker.

Yue Li
Tian Yuan
Daohua Jiang
ResearchOpen Access23 Feb 2023
Nature Communications

Volume: 14, P: 1-13
CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer

Congcong Chen
Yabing Yang
Yunlong Pan
ResearchOpen Access14 Apr 2023
Cell Death & Disease

Volume: 14, P: 1-9
The landscape of RNA Pol II binding reveals a stepwise transition during ZGA

Binding of RNA polymerase II during zygotic genome activation in mouse embryos is determined using the newly developed method Stacc–seq.

Bofeng Liu
Qianhua Xu
Wei Xie
Research28 Oct 2020
Nature

Volume: 587, P: 139-144
Complex strain evolution of polar and magnetic order in multiferroic BiFeO₃ thin films

To fully exploit the potential of multiferroic materials the control of their intrinsic degrees of freedom is a prerequisite. Here, the control of spin orientation in strained BiFeO₃ films is demonstrated elucidating the microscopic mechanism of the complex interplay of polar and magnetic order.

Zuhuang Chen
Zhanghui Chen
Lane W. Martin
ResearchOpen Access21 Sept 2018
Nature Communications

Volume: 9, P: 1-9
Deep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge

Magmatic and tectonic activity at mid-oceanic ridges can give detailed insights into high-temperature hydrothermal circulation of fluids. The authors here present geochemical and geophysical datasets that suggest a hydrothermal system penetrating the upper lithospheric mantle at an ultra-slow spreading mid-oceanic ridge.

Chunhui Tao
W. E. Seyfried Jr
Wei Li
ResearchOpen Access10 Mar 2020
Nature Communications

Volume: 11, P: 1-9
Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations

Yuan and Qiu et al. estimate heritability for High Myopia (HM) using whole-exome sequencing data in Han Chinese ancestry and European ancestry. By combining rare risk genotypes with exome-wide association studies of HM, the authors develop an exome-wide genetic risk score for HM prediction.

Jian Yuan
Ruowen Qiu
Jianzhong Su
ResearchOpen Access30 Dec 2024
Communications Medicine

Volume: 4, P: 1-10
Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Manav Kapoor
Jen-Chyong Wang
Alison Goate
ResearchOpen Access14 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-11
One possible mechanism for eddy distribution in zonal current with meridional shear

YunLong Shi
DeZhou Yang
BaoShu Yin
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults

In a nested case-control study from the China Kadoorie Biobank, lowering blood low-density lipoprotein cholesterol levels confers lower risk for ischemic stroke but elevated risk for intracerebral hemorrhage, which was confirmed by genetic Mendelian randomization analyses.

Luanluan Sun
Robert Clarke
Zhe Qiu
Research11 Mar 2019
Nature Medicine

Volume: 25, P: 569-574

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