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Showing 1–4 of 4 results
Advanced filters: Author: Yusanne P Ma Clear advanced filters

  • To address the question of whether a recurrent tumour is genetically similar to the tumour at diagnosis, the evolution of medulloblastoma has been studied in both an in vivo mouse model of clinical tumour therapy as well as in humans with recurrent disease; targeted tumour therapies are usually based on targets present in the tumour at diagnosis but the results from this study indicate that post-treatment recurring tumours (compared with the tumour at diagnosis) have undergone substantial clonal divergence of the initial dominant tumour clone.

    • A. Sorana Morrissy
    • Livia Garzia
    • Michael D. Taylor
    Research
    Nature
    Volume: 529, P: 351-357

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776

  • Michael Taylor, Marco Marra and colleagues analyze spatial tumor heterogeneity in 9 medulloblastomas, 16 high-grade gliomas and 10 renal cell carcinomas, using a combination of transcriptomic and genomic profiling of multiregional biopsies. They find that medulloblastomas have spatially homogeneous transcriptomes, whereas somatic mutations that affect genes suitable for targeted therapeutics are spatially heterogeneous.

    • A Sorana Morrissy
    • Florence M G Cavalli
    • Michael D Taylor
    Research
    Nature Genetics
    Volume: 49, P: 780-788