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Showing 1–4 of 4 results
Advanced filters: Author: Yusi Qin Clear advanced filters
  • Triggering the PD-1/PD-L1 immune checkpoint is an attractive therapeutic approach in inflammatory bowel disease, and PD-L1, conjugated to the Fc part of an immunoglobulin (PD-L1-Fc) has been shown to be effective in mouse models. Here authors show that fusing to reactive oxygen species (ROS)-responsive nanoparticles improves effect of PD-L1-Fc due to targeting to inflammation sites, while systemic toxicity is reduced.

    • Xudong Tang
    • Yangyang Shang
    • Lei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18
  • Alien species invasions are thought to be important to zoonotic diseases through the introduction of both existing and novel pathogens to invaded ranges. Using data from 795 established alien animals and 10,473 zoonosis events worldwide, this study examines the role of alien zoonotic hosts on zoonosis emergences after accounting for climate, propagule pressure, global change and sampling bias.

    • Lin Zhang
    • Jason Rohr
    • Xuan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11