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Nutrients activate distinct patterns of small-intestinal enteric neurons

Calcium imaging of the mouse jejunum shows that specific nutrients in the intestinal lumen are detected by epithelial cells, which activate specific sets of enteric neurons through a serotonin-mediated signalling process.

Candice Fung
Tom Venneman
Pieter Vanden Berghe
ResearchOpen Access09 Jul 2025
Nature

Volume: 644, P: 1069-1077
Erratum: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa
Yuuki Obata
Hiroshi Ohno
Amendments and Corrections12 Feb 2014
Nature

Volume: 506, P: 254
Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

Activating mutations of the tyrosine kinase Kit are commonly found in mast cell neoplasms and gastrointestinal stromal tumours. Here the authors show that mutant Kit, through the activation of PI3K and STAT3 pathways, elicits proliferative and survival signals from endolysosomes and from the endoplasmic reticulum.

Yuuki Obata
Shota Toyoshima
Ryo Abe
ResearchOpen Access10 Dec 2014
Nature Communications

Volume: 5, P: 1-17
Neuronal programming by microbiota regulates intestinal physiology

In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.

Yuuki Obata
Álvaro Castaño
Vassilis Pachnis
Research05 Feb 2020
Nature

Volume: 578, P: 284-289
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Regulatory T cells proliferate robustly in gut lymphoid tissues. Hase et al. show that this proliferation requires their expression of the epigenetic regulator Uhrf1, which is increased in response to IL-2 produced by effector T cells.

Yuuki Obata
Yukihiro Furusawa
Koji Hase
Research28 Apr 2014
Nature Immunology

Volume: 15, P: 571-579
Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism

Tan et al. identify a regulatory network between colonic EECs and the gut microbiota that controls l-glutamic acid production, appetite and body weight in mice.

Shuai Tan
Jacobo L. Santolaya
Ezra Burstein
Research22 May 2024
Nature Metabolism

Volume: 6, P: 1076-1091
Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent

Yuuki Obata
Miyuki Natsume
Toshirou Nishida
ResearchOpen Access06 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon

Polyamines produced by intestinal bacteria are thought to have beneficial effects on the host. Here the authors show that these polyamines increase regulatory macrophage abundance and are taken up by colonic epithelial cells to enhance colonic barrier function and immunity in mice.

Atsuo Nakamura
Shin Kurihara
Koji Hase
ResearchOpen Access08 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

The gut microbial metabolite butyrate is shown to induce the differentiation of colonic T regulatory cells in mice and to ameliorate the development of colitis; it also increases histone H3 acetylation at the Foxp3 promoter.

Yukihiro Furusawa
Yuuki Obata
Hiroshi Ohno
Research13 Nov 2013
Nature

Volume: 504, P: 446-450
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

Intestinal microfold (M) cells actively capture luminal antigens and move them by transcytosis to initiate immune responses. Ohno and colleagues show that the Ets transcription factor Spi-B is necessary for M-cell differentiation.

Takashi Kanaya
Koji Hase
Hiroshi Ohno
Research17 Jun 2012
Nature Immunology

Volume: 13, P: 729-736
Molecular profiling of enteric nervous system cell lineages

Fluorescently labeled nuclei of the enteric nervous system are isolated from adult mouse or zebrafish gut and characterized by nuclear RNA sequencing and visualization and quantification of transcripts using a custom analytical pipeline.

Yuuki Obata
Álvaro Castaño
Vassilis Pachnis
Protocols08 Jun 2022
Nature Protocols

Volume: 17, P: 1789-1817
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

Kouhei Yamawaki
Isamu Shiina
Yuuki Obata
ResearchOpen Access22 Nov 2021
Scientific Reports

Volume: 11, P: 1-12
TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours

Yurina Saito
Tsuyoshi Takahashi
Yuichiro Doki
ResearchOpen Access20 Dec 2019
British Journal of Cancer

Volume: 122, P: 658-667

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