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Showing 1–4 of 4 results

Advanced filters: Author: Yuvaraj Bhoobalan-Chitty Clear advanced filters

Natively expressed AcrIII-1 does not function as an anti-CRISPR protein

Laura Martínez-Alvarez
Dominic Stickel
Xu Peng
Research16 Apr 2025
Nature

Volume: 640, P: E8-E14
Publisher Correction: Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

Fei He
Yuvaraj Bhoobalan-Chitty
Xu Peng
Amendments and Corrections21 Jun 2018
Nature Microbiology

Volume: 3, P: 1076
Regulatory sequence-based discovery of anti-defense genes in archaeal viruses

Little is known about how archaeal viruses counteract host immunity. Here, the authors leverage a viral gene regulatory feature to predict 354 potential anti-defense genes and experimentally validate a CRISPR-Cas I-A inhibitor and an inhibitor of a toxin-antitoxin system.

Yuvaraj Bhoobalan-Chitty
Shuanshuan Xu
Xu Peng
ResearchOpen Access02 May 2024
Nature Communications

Volume: 15, P: 1-13
Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity

Like phages, archaeal viruses also encode anti-CRISPR proteins (Acrs). These include AcrID1 from the lytic rudivirus SIRV3, which interacts with the Cas10d protein of Sulfolobus islandicus. AcrID1 homologues are present in many archaeal viral families.

Fei He
Yuvaraj Bhoobalan-Chitty
Xu Peng
Research05 Mar 2018
Nature Microbiology

Volume: 3, P: 461-469