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Showing 1–3 of 3 results
Advanced filters: Author: Yuyan Weng Clear advanced filters

  • WNT-activating mutations in CTNNB1 are common in hepatoblastoma, but downstream molecular phenotypes are heterogenous. Using multiomic approaches, the authors identify distinct subgroups of hepatoblastoma cells based on WNT-signaling patterns and create a biobank of patient-derived hepatoblastoma organoids representing these subtypes.

    • Thomas A. Kluiver
    • Yuyan Lu
    • Weng Chuan Peng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • In this study, ectomesenchymal stem cells (EMSCs) were modified with the transglutaminase 2 (TG2) genes and tested for their ability to enhance bone regeneration on fibrin scaffold. In vitro analyses revealed that osteogenic differentiation of the EMSCs on the fibrin scaffold was promoted by TG2 expression. Transplanting fibrin scaffold loaded with TG2 gene-modified EMSC into bone defects on rat skull induced significantly faster bone regeneration compared with non-genetically modified EMSC.

    • Wentao Shi
    • Yunduan Que
    • Naiyan Lu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 13, P: 1-18