Nature Search

Somatic evolution following cancer treatment in normal tissue

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Oriol Pich
Sophia Ward
Nicholas McGranahan
ResearchOpen Access10 Dec 2025
Nature

P: 1-11
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Intermittent fasting to slow down Alzheimer’s disease

In our aging global population and with no effective treatments, the cognitive impairments associated with Alzheimer’s disease represent a major healthcare problem. A recent study in Nature Aging highlights intermittent fasting as a potential way to decrease the progression of Alzheimer’s disease in mice through changes to the gut microbiota.

Sarah Nicolas
Yvonne M. Nolan
News & Views17 Nov 2022
Nature Aging

Volume: 2, P: 982-983
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Considerations for patient and public involvement and engagement in health research

The authors generate a checklist of key considerations to guide patient and public involvement and engagement in future research, informed by lessons from the TLC study, which evaluated therapies for long COVID.

Olalekan Lee Aiyegbusi
Christel McMullan
David C. Wraith
Reviews20 Jul 2023
Nature Medicine

Volume: 29, P: 1922-1929
Mixed methods study of views and experience of non-hospitalised individuals with long COVID of using pacing interventions

Christel McMullan
Shamil Haroon
Melanie Calvert
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Key considerations for digital decentralised clinical trials from a feasibility study assessing pacing interventions for long COVID

Christel McMullan
Shamil Haroon
Melanie Calvert
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus

Thomas Vaughan and colleagues report a genome-wide association study of esophageal adenocarcinoma together with its precancerous lesion, Barrett's esophagus. They identified three loci associated with susceptibility to this cancer.

David M Levine
Weronica E Ek
Thomas L Vaughan
Research13 Oct 2013
Nature Genetics

Volume: 45, P: 1487-1493
Recommendations to address respondent burden associated with patient-reported outcome assessment

Patient-reported outcomes are invaluable tools, but may impose a burden on patients; this consensus statement provides a set of 19 recommendations to reduce respondent burden.

Olalekan Lee Aiyegbusi
Samantha Cruz Rivera
Melanie J. Calvert
Reviews29 Feb 2024
Nature Medicine

Volume: 30, P: 650-659
Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats

Sarah Nicolas
Sebastian Dohm-Hansen
Yvonne M. Nolan
ResearchOpen Access24 Apr 2024
Translational Psychiatry

Volume: 14, P: 1-13
The effects of bone marrow stem and progenitor cell seeding on urinary bladder tissue regeneration

Matthew I. Bury
Natalie J. Fuller
Arun K. Sharma
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
Adult-born neurons from the dorsal, intermediate, and ventral regions of the longitudinal axis of the hippocampus exhibit differential sensitivity to glucocorticoids

Brunno Rocha Levone
Martin G. Codagnone
Olivia F. O’ Leary
Research24 Jul 2020
Molecular Psychiatry

Volume: 26, P: 3240-3252

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