The NS1 protein of the influenza virus is a critical virulence factor that antagonizes the host antiviral response by multiple mechanisms, including the binding and sequestration of double-stranded RNA. This paper describes the structure of full-length NS1 protein and shows that individual domains interact in such a way as to form tubules, which may sequester dsRNA, allowing the virus to evade the innate immune response.
- Zachary A. Bornholdt
- B. V. Venkataram Prasad
