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Showing 1–3 of 3 results
Advanced filters: Author: Zachary A. Hing Clear advanced filters

  • Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpression in a CLL mouse model leads to increased risk of transformation, and that targeted PRMT5 inhibition prolongs survival and delays disease development.

    • Zachary A. Hing
    • Janek S. Walker
    • Rosa Lapalombella
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21

  • Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.

    • Janek S. Walker
    • Zachary A. Hing
    • Rosa Lapalombella
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16