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Showing 1–4 of 4 results
Advanced filters: Author: Zachary Buchan Clear advanced filters

  • Minor changes to complex structures can exert major influences on synthesis strategy and functional properties but synthetic difficulties can obstruct the exploration of natural product function. Here the authors explore two parallel series of picrotoxinin analogs and identify leads with selectivity between mammalian and insect ion channels.

    • Guanghu Tong
    • Samantha Griffin
    • Ryan A. Shenvi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • PPM1D is a known mediator of p53 signalling, and has been linked to treatment resistance in glioma. In this work, the authors utilise genomics, proteomics, and mouse models to determine the role of PPM1D in the development of diffuse midline glioma.

    • Prasidda Khadka
    • Zachary J. Reitman
    • Pratiti Bandopadhayay
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18

  • This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

    • Shusei Sato
    • Satoshi Tabata
    • René M. Klein Lankhorst
    ResearchOpen Access
    Nature
    Volume: 485, P: 635-641