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Showing 1–4 of 4 results

Advanced filters: Author: Zackery Ely Clear advanced filters

A prime editor mouse to model a broad spectrum of somatic mutations in vivo

Prime-editing mouse models enable the study of specific cancer mutations in vivo.

Zackery A. Ely
Nicolas Mathey-Andrews
Tyler Jacks
Research11 May 2023
Nature Biotechnology

Volume: 42, P: 424-436
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

Mouse models of lung and colorectal cancer with sporadic DNA mismatch repair deficiency clarify that the intratumor heterogeneity and clonal architecture rather than tumor mutational burden are powerful determinants of immunotherapy response.

Peter M. K. Westcott
Francesc Muyas
Tyler Jacks
ResearchOpen Access14 Sept 2023
Nature Genetics

Volume: 55, P: 1686-1695
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Jacks and colleagues demonstrate the effects of neoantigen expression level on T-cell priming and immune surveillance during tumor development and progression and explore implications for immunotherapies, using in vivo models of colorectal cancer.

Peter M. K. Westcott
Nathan J. Sacks
Tyler Jacks
Research30 Sept 2021
Nature Cancer

Volume: 2, P: 1071-1085
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

Single-nucleus and spatial, whole-transcriptome profiling of 43 pancreatic adenocarcinomas provides a refined molecular and cellular classification, highlighting a new neoadjuvant treatment-associated neural-like progenitor tumor cell state.

William L. Hwang
Karthik A. Jagadeesh
Aviv Regev
Research28 Jul 2022
Nature Genetics

Volume: 54, P: 1178-1191