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Showing 1–4 of 4 results
Advanced filters: Author: Zain Paroo Clear advanced filters

  • Small RNAs function within the context of RNA-induced silencing complexes (RISCs) containing Argonaute (AGO) subfamily proteins. Experiments now show that human RISC assembly is uncoupled from dicing and is facilitated by ATP to load the small RNA duplexes but is not necessary to unwind them. The four human AGO proteins show no obvious structural preferences for small RNA duplexes in contrast to the situation in flies and worms where small RNAs are actively sorted into distinct AGO proteins according to their structural features.

    • Mayuko Yoda
    • Tomoko Kawamata
    • Yukihide Tomari
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 17-23

  • Generating a complex competent for RNA interference requires cutting and removal of the non-guide siRNA strand. Reconstitution of human RISC activity now shows that C3PO is an endonuclease critical for human Ago2-RISC activation and suggests that the C3PO consists of an octamer with active sites located on the convex interior.

    • Xuecheng Ye
    • Nian Huang
    • Hong Zhang
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 650-657

  • Little is known about the regulation of RNA interference (RNAi). Shan et al. constructed a reporter system to monitor RNAi activity and identified a small molecule that increases RNAi by facilitating the interaction between small RNAs and a protein involved in small RNA loading and processing.

    • Ge Shan
    • Yujing Li
    • Peng Jin
    Research
    Nature Biotechnology
    Volume: 26, P: 933-940