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Advanced filters: Author: Zander Harteveld Clear advanced filters

Computational design of anti-CRISPR proteins with improved inhibition potency

Domain insertion into the loop region of AcrIIC1 leads to a variant with enhanced inhibitory activity toward Neisseria meningitides Cas9, while structure-guided design turns AcrIIC1 into a potent inhibitor of Staphylococcus aureus Cas9.

Jan Mathony
Zander Harteveld
Dominik Niopek
Research13 Apr 2020
Nature Chemical Biology

Volume: 16, P: 725-730
De novo design of protein interactions with learned surface fingerprints

A surface-centric approach captures the physical and chemical determinants of molecular recognition, enabling the de novo design of protein interactions and of artificial proteins with function.

Pablo Gainza
Sarah Wehrle
Bruno E. Correia
ResearchOpen Access26 Apr 2023
Nature

Volume: 617, P: 176-184
Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9

CASANOVA uses LOV and blue light to regulate CRISPR activity.

Felix Bubeck
Mareike D. Hoffmann
Dominik Niopek
Research30 Oct 2018
Nature Methods

Volume: 15, P: 924-927