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Showing 1–4 of 4 results
Advanced filters: Author: Zaniar Ghazizadeh Clear advanced filters

  • Our incomplete understanding of how pancreatic beta cells form limits the generation of beta-like cells from human pluripotent stem cells (hPSC). Here, the authors identify a ROCKII inhibitor H1152 as increasing insulin secreting cells from hPSCs and improving beta-cell maturation on transplantation in vivo.

    • Zaniar Ghazizadeh
    • Der-I Kao
    • Shuibing Chen
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.

    • Ting Zhou
    • Tae Wan Kim
    • Shuibing Chen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activated TGFβ pathway.

    • Sadaf Amin
    • Brandoch Cook
    • Shuibing Chen
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12