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Showing 1–3 of 3 results
Advanced filters: Author: Zara Ghazoui Clear advanced filters

  • Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

    • Michael P. Menden
    • Dennis Wang
    • Julio Saez-Rodriguez
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • This Opinion article discusses the challenges in determining which genomic events in tumours are actionable and thus expected to affect treatment response. The authors summarize published classification approaches and propose a new framework to classify mutation actionability in early-phase clinical trials.

    • T. Hedley Carr
    • Robert McEwen
    • J. Carl Barrett
    Reviews
    Nature Reviews Cancer
    Volume: 16, P: 319-329