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Showing 1–6 of 6 results
Advanced filters: Author: Zasha Weinberg Clear advanced filters

  • To promote expression of the most recently acquired CRISPR spacers, the transcribed leader region upstream of CRISPR arrays interacts with the conserved repeats bordering the newest spacer, with the resulting interaction promoting tracrRNA hybridization with the second repeat and accelerating crRNA processing

    • Chunyu Liao
    • Sahil Sharma
    • Chase L. Beisel
    Research
    Nature Microbiology
    Volume: 7, P: 530-541

  • A bioinformatics pipeline guided by genomic hints of where to look led to the identification and validation of several new classes of self-cleaving ribozymes and several catalytic RNA motifs related to the known hammerhead or HDV ribozymes.

    • Zasha Weinberg
    • Peter B Kim
    • Ronald R Breaker
    Research
    Nature Chemical Biology
    Volume: 11, P: 606-610

  • The helix–turn–helix domain of an anti-CRISPR-associated (Aca) protein represses transcription of anti-CRISPR (Acr)-encoding genes and inhibits their translation to protein via distinct binding modes to DNA and RNA, respectively.

    • Nils Birkholz
    • Kotaro Kamata
    • Peter C. Fineran
    Research
    Nature
    Volume: 631, P: 670-677

  • To date, five classes of naturally occurring self-cleaving ribozymes have been reported. The bioinformatic discovery in bacteria and eukaryotes of twister RNAs, a new ribozyme class that contains a double pseudoknot fold, adds to the list of catalytic RNAs that have roles in cells.

    • Adam Roth
    • Zasha Weinberg
    • Ronald R Breaker
    Research
    Nature Chemical Biology
    Volume: 10, P: 56-60

  • Cyclic diadenosine monophosphate (c-di-AMP) is a newly identified nucleotide second messenger in bacteria. Though protein receptors for c-di-AMP are known, the ydaO riboswitch has now been validated as a physiological sensor of cellular c-di-AMP levels.

    • James W Nelson
    • Narasimhan Sudarsan
    • Ronald R Breaker
    Research
    Nature Chemical Biology
    Volume: 9, P: 834-839

  • Existing DNA sequence databases carry only a tiny fraction of the total amount of DNA sequence space from bacterial species. Bioinformatics searches of genomic DNA from bacteria commonly identify new noncoding RNAs (ncRNAs) such as riboswitches. Here, an updated computational pipeline is used to discover ncRNAs that rival the known large ribozymes in size and structural complexity; other such RNAs probably remain to be discovered.

    • Zasha Weinberg
    • Jonathan Perreault
    • Ronald R. Breaker
    Research
    Nature
    Volume: 462, P: 656-659