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Advanced filters: Author: Ze-Run Zhao Clear advanced filters

  • Direct ribosylation of nucleobases for regioselective ribonucleoside synthesis is a challenge. Now, a prebiotic Ti-catalysed ribosylation of nucleobases is reported, providing selective access to N9 purine nucleosides. Mechanistic analysis reveals key substrate–surface interactions are the origin of the regiocontrol.

    • Qian-Qian Chen
    • Ze-Run Zhao
    • Xiao Wang
    Research
    Nature Synthesis
    Volume: 2, P: 348-356