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Lens effect of remnant blocks on deep mantle upwelling causing anomalous subsidence

Based on numerical models and the comparison with natural settings, this study reveals that divergent mantle flow induced by lower-mantle upwelling can cause anomalous subsidence. Interaction between the upwelling and remnant blocks can extend the duration of the upwelling and focus the subsidence into a narrow region.

Liang Liu
Zebin Cao
Yi-Gang Xu
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination

The K29/K48 hetero-polyubiquitin signal has been reported to be an enhanced degradation signal, but the enzymatic mechanism of this ubiquitin chain formation is unclear. Here, the authors reveal how the HECT E3 ligase Ufd4/TRIP12 generates K29/K48 branched ubiquitin chains and provide structural insights into this process.

Xiangwei Wu
Huasong Ai
Man Pan
ResearchOpen Access09 May 2025
Nature Communications

Volume: 16, P: 1-15
Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut

Peptidoglycan fragments derived from gut bacteria modulate aspects of the host’s health. Here, Li et al. profile peptidoglycan fragments in the host gut and show that one of them, the disaccharide GlcNAc-MurNAc, acts as a mild TLR4 agonist and protects against gut inflammation.

Chenyu Li
Christopher Adamson
Yuan Qiao
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

Using site-specific chemical crosslinking strategies, Ai, Tong and Deng et al. captured structural intermediates of ubiquitin E3 ligase RNF168-mediated H2A K13 and K15 monoubiquitination and adjacent dual monoubiquitination in the DNA damage repair response; the structural analysis revealed a helix-anchoring mechanism.

Huasong Ai
Zebin Tong
Man Pan
Research11 Oct 2024
Nature Chemical Biology

Volume: 21, P: 668-680
Selective identification of epigenetic regulators at methylated genomic sites by SelectID

The authors introduce SelectID, an approach combining CRISPR-guided targeting with methylation-sensitive labeling to identify proteins interacting with methylated repetitive sequences. They suggest that CHD4 directly binds young LINE-1 retrotransposons, suppressing their activity.

Wenchang Qian
Penglei Jiang
Pengxu Qian
ResearchOpen Access18 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes

Here, using cryo-EM, in vitro and cellular assays, the authors elucidate how SS18–SSX1, via an unorthodox manner of selectively recognizing ubiquitylated nucleosomes, hijacks the BAF1 complex to Polycomb-repressed regions in synovial carcinoma.

Zebin Tong
Huasong Ai
Lei Liu
Research04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 300-310
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity

Using combined methods of modern chemical protein synthesis and structural biology, Ai et al. found a crosstalk mechanism of histone modifications, by which H2BK34ub stimulates the activity of the H3K79 methyltransferase Dot1L through inducing nucleosome distortion.

Huasong Ai
Maoshen Sun
Lei Liu
Research23 Jun 2022
Nature Chemical Biology

Volume: 18, P: 972-980
Western US intraplate deformation controlled by the complex lithospheric structure

The lithospheric structure controls crustal deformation in the western US. Particularly, its abrupt thickness change along the eastern boundary of the Basin and Range leads to enhanced lithosphere-asthenosphere interaction and localized earthquakes.

Zebin Cao
Lijun Liu
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-16
Correction: Corrigendum: Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis

Wenjun Liu
Jiachao Zhang
Heping Zhang
Amendments and CorrectionsOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-2
Parthenolide alleviates peritoneal fibrosis by inhibiting inflammation via the NF-κB/ TGF-β/Smad signaling axis

Ying Zhang
Weidong Feng
Jianbo Liang
Research28 Oct 2022
Laboratory Investigation

Volume: 102, P: 1346-1354
Unique Features of Ethnic Mongolian Gut Microbiome revealed by metagenomic analysis

Wenjun Liu
Jiachao Zhang
Heping Zhang
ResearchOpen Access06 Oct 2016
Scientific Reports

Volume: 6, P: 1-13
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry

Xueyuan Guo
Juan Du
Jian Zhang
ResearchOpen Access02 Feb 2024
Scientific Reports

Volume: 14, P: 1-15

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