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Showing 1–2 of 2 results
Advanced filters: Author: Zexuan Ding Clear advanced filters

  • On-target, off-tumour toxicity is a major concern in immunotherapy. Here, aided by computer docking analysis, the authors introduce a single oxygen atom into the TLR7/8 agonist R848, generating a radiotherapy-activatable prodrug agonist that in mice helps mitigate systemic toxicity while triggering effective anti-tumor immunity responses upon radiation.

    • Zexuan Ding
    • Xiaozhe Yin
    • Zhibo Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Systemic administration of TRL7/8 agonists enhances anti-tumor immunity by enhancing dendritic cell (DC) activation, but also causes systemic toxicity. Here, the authors show that, in tumor mouse models, a radiotherapy-activated, N-oxide imidazoquinoline prodrug promotes controlled, local activation of intratumoral DC-T cell dynamics, while promoting systemic anti-tumor responses.

    • Xiaozhe Yin
    • Zexuan Ding
    • Yang-Xin Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13