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Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal regulator of mitochondrial morphology and function, critical for activity-dependent synaptic connectivity.

Iryna Mohylyak
Maheva Andriatsilavo
Bassem A. Hassan
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

Profiling phenotype switching in melanoma. Wouters et al. perform large-scale gene expression analysis in patient samples and identify transcriptional networks that modulate the intermediate cell state and ultimate mesenchymal switching in melanoma.

Jasper Wouters
Zeynep Kalender-Atak
Stein Aerts
Research03 Aug 2020
Nature Cell Biology

Volume: 22, P: 986-998
Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

The key regulators that allow transition from proliferative to invasive phenotype in melanoma cells have not been identified yet. The authors perform chromatin and transcriptome profiling followed by comprehensive bioinformatics analysis identifying new candidate regulators for two distinct cell states of melanoma.

Annelien Verfaillie
Hana Imrichova
Stein Aerts
ResearchOpen Access09 Apr 2015
Nature Communications

Volume: 6, P: 1-16
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Stein Aerts, Jan Cools and colleagues report exome sequencing of T-cell acute lymphoblastic leukemia. They identify recurrent somatic mutations in CNOT3 and ribosome genes RPL5 and RPL10.

Kim De Keersmaecker
Zeynep Kalender Atak
Jan Cools
Research23 Dec 2012
Nature Genetics

Volume: 45, P: 186-190
Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulation of genes involved in metabolism and protein translation.

Luis Zurkirchen
Sandra Varum
Lukas Sommer
ResearchOpen Access16 May 2019
Nature Communications

Volume: 10, P: 1-16
SCENIC: single-cell regulatory network inference and clustering

SCENIC enables simultaneous regulatory network inference and robust cell clustering from single-cell RNA-seq data.

Sara Aibar
Carmen Bravo González-Blas
Stein Aerts
Research09 Oct 2017
Nature Methods

Volume: 14, P: 1083-1086

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Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

SCENIC: single-cell regulatory network inference and clustering

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Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity

Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner

SCENIC: single-cell regulatory network inference and clustering

Search

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