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Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats

Hua Liu
Hui Lei
Yi Yang
Research06 Mar 2017
Acta Pharmacologica Sinica

Volume: 38, P: 990-997
Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing

The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed oesophagus.

Xi-Xi Chen
Qian Zhong
Mu-Sheng Zeng
ResearchOpen Access12 Sept 2017
Nature Communications

Volume: 8, P: 1-12
Gut stem cell necroptosis by genome instability triggers bowel inflammation

In mouse models of bowel inflammation, depletion of the SETDB1 histone methyltransferase leads to genome instability, which releases repression of endogenous retroviruses that triggers ZBP1-dependent necroptosis and inflammation in gut.

Ruicong Wang
Hongda Li
Wei Mo
Research25 Mar 2020
Nature

Volume: 580, P: 386-390
Caveolin-1 is important for nitric oxide-mediated angiogenesis in fibrin gels with human umbilical vein endothelial cells

Yi-ming Pan
Yong-zhong Yao
Yi-tao Ding
Research01 Dec 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1567-1574
Hepatocyte-like cells from directed differentiation of mouse bone marrow cells in vitro

Xiao-lei Shi
Yu-dong Qiu
Yi-tao Ding
Research01 Apr 2005
Acta Pharmacologica Sinica

Volume: 26, P: 469-476
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death. Here, the authors show that cysteine residues in RIP1 sense ROS and oxidation of the cysteines triggers RIP1 autophosphorylation, which promotes functional necrosome formation.

Yingying Zhang
Sheng Sean Su
Jiahuai Han
ResearchOpen Access08 Feb 2017
Nature Communications

Volume: 8, P: 1-14
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

Wan-ting He
Haoqiang Wan
Jiahuai Han
ResearchOpen Access27 Nov 2015
Cell Research

Volume: 25, P: 1285-1298

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Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats

Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing

Gut stem cell necroptosis by genome instability triggers bowel inflammation

Caveolin-1 is important for nitric oxide-mediated angiogenesis in fibrin gels with human umbilical vein endothelial cells

Hepatocyte-like cells from directed differentiation of mouse bone marrow cells in vitro

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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