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Showing 1–8 of 8 results
Advanced filters: Author: Zhaozhu Qiu Clear advanced filters

  • TARPs are tetraspanins that are claudin-like but regulate glutamate receptors. Here, the moieties that define TARP function and distinguish them from claudins are uncovered through cryo-EM, structure prediction, and electrophysiology.

    • W. Dylan Hale
    • Alejandra Montaño Romero
    • Edward C. Twomey
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-7

  • LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.

    • Jiachen Chu
    • Zhaozhu Qiu
    News & Views
    Nature Immunology
    Volume: 23, P: 157-158

  • Volume-regulated anion channels (VRACs) are critical for cell volume regulation, neuron–glia interaction, metabolism, and immunity. They are formed as heteromers of LRRC8 proteins with unknown stoichiometry. Two papers now reveal the structures of heteromeric LRRC8A and LRRC8C channels, providing insights into channel assembly and gating.

    • Tatsuya Hagino
    • Zhaozhu Qiu
    News & Views
    Nature Structural & Molecular Biology
    Volume: 30, P: 714-716

  • A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons.

    • Seung-Hyun Woo
    • Sanjeev Ranade
    • Ardem Patapoutian
    Research
    Nature
    Volume: 509, P: 622-626

  • Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

    • Sanjeev S. Ranade
    • Seung-Hyun Woo
    • Ardem Patapoutian
    Research
    Nature
    Volume: 516, P: 121-125