Nature Search

Structural insights into the cross-exon to cross-intron spliceosome switch

Cryo-electron microscopy structures of cross-exon pre-B and B-like complexes contribute new insights into the molecular mechanisms that mediate the switch from a cross-exon to a cross-intron organized spliceosome.

Zhenwei Zhang
Vinay Kumar
Reinhard Lührmann
ResearchOpen Access22 May 2024
Nature

Volume: 630, P: 1012-1019
Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality, and there is no specific drug to treat it. Here, the authors show that the AR-CAND1-ACAA2 axis regulates the development of NAFLD, and enhancing the function of CAND1 is a promising strategy for the development of a therapeutic agent for NAFLD.

Xiang Huang
Xin Liu
Zhenwei Pan
ResearchOpen Access01 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Irinotecan alleviates chemoresistance to anthracyclines through the inhibition of AARS1-mediated BLM lactylation and homologous recombination repair

Xinyuan Li
Chunlin Zhang
Xin Gou
ResearchOpen Access10 Jul 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-21
Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms

CXCR2 is central to neutrophil chemotaxis and hence to some inflammatory diseases. Here the authors demonstrate the value of an epitope-guided antibody panning method to develop a tight binding anti-hCXCR2 antibody, along with crystal structures of this antibody and antigen, that can block neutrophil chemotaxis and protect mice in an EAE model.

Xiaojie Shi
Yue Wan
Richard A. Lerner
ResearchOpen Access05 May 2021
Nature Communications

Volume: 12, P: 1-14
Development of a bispecific antibody targeting PD-L1 and TIGIT with optimal cytotoxicity

Zhenwei Zhong
Mengyao Zhang
Xiaowen He
ResearchOpen Access26 Oct 2022
Scientific Reports

Volume: 12, P: 1-11
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.

Viktor A. Adalsteinsson
Gavin Ha
Matthew Meyerson
ResearchOpen Access06 Nov 2017
Nature Communications

Volume: 8, P: 1-13
A power quality disturbances classification method based on multi-modal parallel feature extraction

Zhanbei Tong
Jianwei Zhong
Zhenwei Li
ResearchOpen Access17 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Comprehensive biomechanical analysis of three clinically used fixation constructs for posterior malleolar fractures using cadaveric and finite element analysis

Adeel Anwar
Zhenwei Hu
Gang Lv
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-11

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