The immunosuppressive tumour microenvironment in Nasopharyngeal carcinoma (NPC) is a cause of low efficacy of immunotherapies in these tumours. In this study, the authors delineate a FLI1-mediated Kyn metabolic mechanism as an immune evasion mechanism in NPC and they show that pharmacological inhibition of FLI1 improves both spontaneous and checkpoint therapy-induced immune responses.
- Enni Chen
- Jiawei Wu
- Wuguo Deng
